Cognitive endophenotypes inform genome-wide expression profiling in schizophrenia.

Genome-Wide Methylation Profiling of Schizophrenia

Schizophrenia is one of the major psychiatric disorders. It is a disorder of complex inheritance, involving both heritable and environmental factors. DNA methylation is an inheritable epigenetic modification that stably alters gene expression. We reasoned that genetic modifications that are a result of environmental stimuli could also make a contribution. We have performed 26 high-resolution ge...

Genome-wide expression profiling in Escherichia coli K-12.

We have established high resolution methods for global monitoring of gene expression in Escherichia coli. Hybridization of radiolabeled cDNA to spot blots on nylon membranes was compared to hybridization of fluorescently-labeled cDNA to glass microarrays for efficiency and reproducibility. A complete set of PCR primers was created for all 4290 annotated open reading frames (ORFs) from the compl...

Genome wide expression profiling of p53 regulated miRNAs in neuroblastoma

Restoration of the antitumor activity of p53 could offer a promising approach for the treatment of neuroblastoma. MicroRNAs (miRNAs) are important mediators of p53 activity, but their role in the p53 response has not yet been comprehensively addressed in neuroblastoma. Therefore, we set out to characterize alterations in miRNA expression that are induced by p53 activation in neuroblastoma cells...

Genome-Wide Expression Profiling during Germination in Plants

Genome-wide expression profiling of T-cells in childhood wheeze.

E lucidation of the molecular mechanisms underlying asthma and related phenotypes is a monumental task. To date, .100 susceptibility genes have already been identified with diverse functions. These can broadly be classified into those involved in the regulation of the innate and adaptive immune system, epithelial biology, lung function and remodelling, and disease severity [1]. An important adv...